Can Progesterone cause pelvic organ prolapse?

I am 35 and have never had children but experienced pelvic organ prolapse last month. It happened about 6 weeks after I began using progesterone cream. The timing seems very suspicious to me.

Is it possible for there to be a connection?

On a support forum for prolapse, many others have noticed that the prolapse is worse at the times of the month when progesterone is higher and better when it is lower.

I have read that progesterone can relax or inhibit tone and 'contractibility' of tissues... but it seemed based in relation to pregnancy - when the body can be making more than 200mg/day (or 300mg/day near the end). I was taking 25mg/day.

It would be nice to know how much/little progesterone can effect tone and if, indeed, that is what causes the fluctuations of POP throughout the cycle.

Do you have any wisdom or opinion about this?

thanks so much

Comments for Can Progesterone cause pelvic organ prolapse?

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Sep 21, 2011
Can Progesterone cause pelvic organ prolapse?
by: Wray

Hi there I've never read any studies showing progesterone causes prolapse. Progesterone does relax muscles, but certainly doesn't make them weak. On the contrary, it prevents and reverses myopathy or muscular weakness, see here and here. The 25mg/day you say you were using would be too low to have any beneficial effect, but it would stimulate the oestrogen receptors. This would have an adverse reaction, which is explained on our Oestrogen Dominance page. A lack of vitamin D can cause muscle weakness, see here. Please have a vitamin D test done, for more info see the Vitamin D Council, GrassrootsHealth Birmingham Hospital and Vitamin D Links websites. I recommend 100-200mg/day progesterone, more if symptoms are severe. We do have more info on our page How to use progesterone cream. Progesterone is normally higher mid-luteal phase when it peaks. But so too is oestrogen, as they both peak then, see our Chart. Many women have a defective luteal phase, which means the corpus luteum is not producing enough progesterone, or none at all. I would suspect it's these women who have the worse time, as oestrogen is dominant when it shouldn't be. Take care Wray


Nov 04, 2011
benefiting from low dose progesterone?
by:

hi Wray, Thanks so much for your reply. I wonder if my positive response to 25mg/day is related to my being extremely chemically sensitive. With both pharmaceuticals and supplements, I often only need a fraction of the regular dose to feel the effects.

Since being on the 25mg/day of progesterone, I am like a different person in a wonderful way! Depression, anxiety, insomnia, irritability, anger etc etc are all almost gone - like a switch was turned off.

I did begin pretty gradually because I didn't know how I would react (being so sensitive). perhaps this allowed me to avoid oestrogen dominance symptoms even though my dose is so low?

A bit of a mystery.

I take 4000-5000iu/day of vitamin D from around August to April. I am in Canada and those are the darker months. I take 2000-3000iu/day the rest of the year when I am having lots of skin exposure to the sun.

My body very clearly lets me know how much vitamin D is too much because I get intense anxiety if it's too much. I have seen taurine mentioned elsewhere and am not sure how it ties in with progesterone therapy but in case it's relevant, I've been taking 1000mg/day for a few years (I use it before bed to help me sleep better and also to help with ulnar nerve inflammation).

Nov 11, 2011
benefiting from low dose progesterone?
by: Wray

Hi there Well I'm delighted you responded to such a low amount of progesterone, this is not normally the case! And I do hope the prolapse has sorted itself out now. I'm delighted you're taking 4000-5000iu's per day of vitamin D, but I would recommend that year round. Although you evidently appear to respond to nutrients far quicker than most. I'm intrigued you find your anxiety increases if you have too much, I've not read that in any paper. You might be interested to learn that 10,000iu's per day is now being recommended, see here. These are a few studies that have been done on Canadians, see here, here, here and here. I do recommend taurine, specially for it's calming effect, so I'm delighted you take it, I do too. It also prevents the calf cramps I get. An odd thing to say, but it's an osmolyte, controlling the balance of electrolytes in and out of cells. Please consider having a vitamin D test done, it would be interesting to hear what your level is. You seem so conscious of your needs. Take care Wray

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