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Bleeding During Use Of Progesterone

by Jill
(Belleville)

I have been using natural progesterone for about a year now. I use 1/8 of a tsp am and pm from day 15 to day 28 of my cycle.

Although most of my symptoms have disappeared I now have breakthrough bleeding during the time I am using the cream. Not sure why?

Comments for Bleeding During Use Of Progesterone

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Dec 14, 2007
 Break through bleeding
by: Wray

Hi Jill. I'm not sure which cream you're using, but the dose to my mind is far too low. I recommend anything from 100-200mg/day of our cream, which is 3.33% progesterone. This is between 3-6ml/day of the cream.

As you still have your cycle you should be using about 4.25ml/day (just under 1 teaspoon), which would give you about 140mg/day of progesterone. The cream should only be used from ovulation, which is 14 days before you start bleeding. If your cycle is 28 days, then using the cream from day 15 is fine, if it's longer you will need to work back from the day you start bleeding.

I think you'll find that the bleeding will stop if you follow this. I would also hope all your symptoms will go soon, very soon! Take care Wray
Aug 18, 2008
 Break through bleeding
by: Rachel

I have a similar problem. I have had short periods of around 23 days with spotting for about 3 days before each cycle. I started taking Natpro progesterone cream but this has brought the spotting forward to start at day 18.

I have been using just under 1/4 teaspoon of Natpro a day (2000mg is written on the 60g tube).

What is causing the breakthrough bleeding? Why has the spotting started earlier than it was when not using the cream at all?

I am also trying to get pregnant but I am now worried that the increased bleeding is going to interfere with maintaining a pregnancy.

Please help as I am beside myself with worry!

Thank you
Rachel
May 03, 2009
 Following the above advice and still short
by: Tadie

I started progesterone (oral progesterone) because I completely quit having periods after the use of Orthotriclen (PCOS and Insulin Resistance have been ruled out). 3 months after starting, I was able to get pregnant. However, my cycles before pregnancy were still erratic and unpredictable.

I found your site and decided to use NatPro rather than the prescription I'd been taking due to your information on the inefficiency of oral pills. After 7 days of treatment (at 1 tsp. of NatPro per day), my period started. It lasted 5 days. I stopped the progesterone cream for 14 days (since I have no cycle length to go by I aimed for a 28 day cycle) and started on day 15.

I'm now on day 22 and my period just started. How should I adjust my dosage? I'm hoping to start trying for my 2nd baby in a month. Does the shortened cycle mean a shortened luteal phase? Or is it considered normal to have a 22 day cycle?
May 05, 2009
 Following the above advice and still short
by: Wray

Hi Tadie. Our cycles vary between 21 and 36 days, the average being 28. So choosing the 28 days was a good option, hopefully in time your own will assert itself.

Progesterone can initially upset the cycle, which is why I recommend using it for 3-6 months for it to settle down. It could be your normal cycle is 22 days, but it's too early to tell. The thing to remember is ovulation occurs in all women 12-14 days before a period. So if you do have a 22 day cycle you would ovulate on day 8, which is when you should use the cream. But as it's too early to tell it would be far better to get a mini microscope to check when you do ovulate. We have more info on pregnancy at this link, please have a look, it should help you:

https://www.progesteronetherapy.com/faq-conception.html

Here are some companies who sell the microscope:

http://www.maybemom.com/about-saliva-ovulation-tester.php
http://www.amazon.com/MaybeMOM-Ovulation-Tester-Mini-Microscope/dp/B000E7VDKU
http://www.craigmedical.com/products.htm#PREGNANCY%20AND%20FERTIL
ITY
http://www.vitrodiagnostic.com/Fertility-test-kits.html
http://www.ovatel.com/how_ovatel_works2.htm
Apr 04, 2010
 Progestrone
by: uzma

I have a bleeding during use of progestrone pessaries. Is it normal or not?
May 04, 2010
 Use of Natpro in pregnancy
by: Anonymous

I just received my first tube of Natpro. I have had problems conceiving and have recently had a miscarriage.

I understand to use the cream for the last 14 days of my cycle after ovulation, however, if I did conceive should I continue in pregnancy? I'd like to know in case I was lucky enough to conceive again. Thankyou
May 06, 2010
 Progestrone
by: Wray

Hi Uzma. Bleeding is normal if you still have a cycle. It's best to use the pessaries following your cycle, ie to start using them when you ovulate. And continue for the next 14 days, then stop and you should have a period shortly afterwards. For more info on how to use progesterone, please see here. Take care, Wray
May 06, 2010
 Use of Natpro in pregnancy
by: Wray

Yes you should continue using it, and it should prevent another miscarriage. We do have a web page on pregnancy, please see here.

The problems conceiving could be you are not ovulating each month, which could mean your ovaries have been damaged by free radicals, causing inflammation. Please consider taking high amounts of the antioxidants arginine 1600mg/day, N-acetyl cysteine 1200mg/day and 5000iu's/day vitamin D. Please avoid all inflammatory foods, sugar, foods containing sugar, and all foods which convert to sugar, ie all grains, legumes, sweet fruit and vegetables, including the starchy vegetables like potatoes. You might like to read the web page on PCO, although you don't have it, I've found many women have low grade inflammation which doesn't cause full blown PCO, but it does affect them. Please see here. Take care, Wray
Nov 01, 2010
 menopause and bleeding with progesterone
by: Glendale Mom

I have been prescribed a 10% progesterone cream (1 gram) to use at bedtime. However, when I use this, I have bleeding. What's going on?
Nov 03, 2010
 menopause and bleeding with progesterone
by: Wray

Hi there Progesterone can cause bleeding after menopause. We still make oestrogen in our fat cells, even if our ovaries have stopped producing it. This small amount is sufficient to build the lining of the uterus. Progesterone is 'cleaning' out the uterus, not a bad thing, although generally the lining is absorbed back into the body. It should only occur once, rarely twice. The 1g of cream is giving you 100mg progesterone, if you find this helping your other symptoms then continue. I have found between 100-200mg/day is needed, certainly more if stress is experienced. Stress drops progesterone levels and symptoms can return. it's essential to use progesterone twice a day, if not more. Levels drop after about 13hrs. For more info please see our page on Menopause.
Take care Wray
Nov 23, 2010
 Use of progestrone while bleeding lightly
by: san

Hi All, I'm 28 years old and I have been diagnosed with PCOS and havenot got my periods for nearly 2 months. Hence the doctor had prescribed progestrone (200 mg)for 5 days. Before starting progestrone I have started bleeding. But the bleeding is little (5 to 6 drops). This does not look like a menstrual bleeding. For past 4 days this type of bleeding is continuing. Please advice me whether I can still take progestrone during this type of bleeding. Eagerly waiting for an answer.
Dec 02, 2010
 Use of progestrone while bleeding lightly
by: Wray

Hi San Yes you can still use the progesterone. But 5 days is insufficient to help with PCOS, it needs to be used for months to help. I'm assuming he's given it to make you bleed after the 5 days, which it probably will. Having regular periods is not the problem in PCOS, but whether you are ovulating. PCOS is caused by oxidative stress, progesterone is an antioxidant, but it's advisable to take others too, notably vitamin D, please have a test done. This is low in most of us, and affects the ovaries greatly when it is. For more info on vitamin D please see the Vitamin D council website. You mention 'taking' the progesterone, if this is the case, oral progesterone is not the best delivery system. Please see this page we have for more info on Progesterone application methods. We also have a page on PCOS, please read through it as it gives info on what causes it, and how to reverse it. Take care Wray
Mar 29, 2011
 Continued spotting while on Progestrome
by: Anonymous

I am perimenopausal and did not have my periods for 2 months. When it did start I continued to have spotting for 8 days. My doctor put me on Progestrone 10mg/day for 10 days.Initially the spotting got better but restated after 2 days.What is going on?Previously my Endometrial biopsy has been normal but my doctor is going to schedule me for it again. Any suggestions?
Apr 20, 2011
 Continued spotting while on Progestrome
by: Wray

Hi there Peri-menopause is a very difficult time. Our periods come and go when they feel like it, sometimes spotting, sometimes flooding. Sometimes weeks between periods, sometimes days. It's impossible to follow the cycle with progesterone, it's best if it's used daily. I don't know what other symptoms you have, maybe it is only the spotting? But the page I've given you explains P-M, and how to use progesterone. The amount you were given is to my mind worse than useless, I recommend 100-200mg/day to get any meaningful results from it. Please consider using more, but if you do, please see our page on Oestrogen Dominance first, as this can occur. Take care Wray
Jun 14, 2011
 PCOS, bleeding lightly everyday during the course of application
by: Madhumita

Hi, I have PCOS and trying for pregnancy. I take metformin for insulin resistance. Starting this month, my doctor who is a naturopath asked me to apply 25mg of natural progesterone creme starting day 12. I figured I generally ovulate on day 15 so I have started applying it from day 15.

But every day I am having light bleeding wafter I started applying progesterone. I am very much worried. I do not want my hormone balance to get disturbed any further. This is my first month of application. Please advise.
Jul 26, 2011
 ttc
by: tryingtobeamom

I have endometriosis, and my doc and I believe a luteal phase defect as I get my period 7 days after ovulation. I just started using progesterone vaginal suppositories 50mg 2x daily. I have been more than spotting everyday. It seems like my period is trying to come. I have been very consistent taking them 12 hours apart. I started taking them 4 days after ovidril trigger shot. Am I do something wrong? Do I need a higher dose?
Nov 22, 2011
 hope this helps
by: Anonymous

After two years of excessive spotting (more so on the pill than off, at least then it was only around the period) I started taking N-Acetyl cysteine, zinc, Alpha Lipoic acid and liver longevity and its the only thing to have helped. I had endometritis, inflammation, but no PCOS. I am overall very healthy, vegetarian but have been on and off the pill which seemed to cause these problems. I really hope this helps someone else.
Dec 09, 2011
 On Progesterone after egg retrieval
by: Anonymous

Hi
I had an egg retrieval on December 2nd. I started endometrum 100mg 3 X's a day on December 3rd (day after my retrieval). I had IVF transfer (2 embryos) on Monday December 5th.
I am concerned becaaue Tuesday night I noticed a little pinkish color spotting (just when I wipe after going to bathroom) I have been noticing this probably once a day since Tuesday night. This morning there was a little bit more blood present. Is this normal? Could the progesterone be causing this to happen? Not sure what to do? I am concerned and hoping that the IVF worked! Would appreciate some advice. Thank you!
Mar 22, 2012
 abnormal bleeding
by: Anonymous

I am on 0.9mg cenestin and prometrium 100mg for the first 10 days of the month. My cycles have been starting a couple days before I start my prometrium or on day one or two. Is this normal?
Mar 24, 2012
 abnormal bleeding
by: Wray

Hi there I don't believe any women needs extra oestrogen, particularly HRT. And why have you been told to use the progesterone for the first 10 days? It should be used from ovulation. We do have more info on our page How to use progesterone cream. Take care Wray
Mar 30, 2012
 Progesterone use by troche & bleeding
by: Jackie

Hi Wray! Here's way too much information for you, but it may help you give a better answer...I take a troche(oral losenge)daily which contains a compound of the following bioidentical hormones: 1mg Estriol/100mg of Progesterone/2mg Testosterone. I'm 33 yrs. old, have endometriosis, fibroids and a 21-23 day cycle. I started to take the full dose on day 7 AFTER my period started & felt amazing...then on day 13 I started to bleed heavily, similar to a period, which continued for 3 days & subsided on day 4/5. So, is that considered "breakthrough" bleeding & do I continue taking my troches through this or should I consider that day 1 of a new cycle and start again on day 7? What is considered reasonable for this type of bleeding...should I tolerate this for a couple of months? Thanks so much...appreciate your feedback.
Apr 02, 2012
 Progesterone use by troche & bleeding
by: Wray

Hi Jackie The more info I get the better! I don't believe you need extra oestrogen, or any testosterone. Because the hormones are mixed up, it makes taking it difficult. Troches are not the best Delivery system as much of the progesterone gets destroyed in the gut and liver. Please see our page on HRT for more info on oestrogen. And these on testosterone here, here, here, here here, here, here, here and here. Plus here. It can increase the risk of ovarian cysts, visceral fat, insulin resistance, heart disease and cancer. Progesterone should be started at ovulation, ie mimicking the luteal phase when we naturally secrete it. So starting on day 7 is correct as you have a 21-23 day cycle. Unless symptoms are severe, then I suggest using it daily for 2-3 months, through any bleeding to ensure progesterone becomes the dominant hormone. Continued below.
Apr 02, 2012
 Progesterone use by troche & bleeding Part 2
by: Wray

Hi Jackie Endometriosis and Fibroids are caused by oxidative stress, high dose antioxidants are needed to reverse it. Plus high amounts of progesterone, I normally suggest 500mg/day for endo, particularly if pain is present. And to use it daily as described above. Oestrogen is a mitogenic hormone, it's also excitatory and inflammatory. It exacerbates endo and fibroids, causing cells to divide and multiply, plus inflaming them. Progesterone can upset the cycle when first using it but it does settle down, with the cocktail you're on, it will be equally upset. Treat a heavy bleed as a normal period and wait till day 7 before starting them again. Please have a vitamin D test done, it's a potent antioxidant and you are probably low in it. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml or 175-250nmol/L and not the 30ng/ml or 75nmol/L most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. Take care Wray
Apr 18, 2012
 progesterone pill (20mg) and bleeding..
by: Anonymous

I am 46 years old, i have been taking progesterone pills (20mg)17 days. Last Monday ( my 15 days), I started bleeding very ligh or spoting. Because I have endometriosis, I also have pain. I am wondering if this is normal. My doctor is not answering my phone calls. thank you,
Apr 19, 2012
 progesterone pill (20mg) and bleeding..
by: Wray

Hi there 20mg will do nothing for you, particularly as it's oral progesterone. This is the least effective Delivery system. Most of it is destroyed by the gut and liver, leaving very little to have any effect. We do have a page on Endometriosis, I recommend 500mg/day particularly if there's pain. Endo is caused by oxidative stress, high doses of antioxidants are needed. Please consider changing to a progesterone which is absorbed well. If you do, please read our page on Oestrogen Dominance. This shouldn't occur if you use the 500mg/day, but there's no guarantee. Please have a vitamin D test done, this is often lacking in inflammatory problems. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml or 175-250nmol/L and not the 30ng/ml or 75nmol/L most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. Take care Wray
Jun 19, 2012
 Brown Discharge 10 years menopause on Progesterone
by: Anonymous

Hello,

it has been 10 years since my last period.
only once when I was diagnosed with hypothyroidism did I have brown spotting/discharge/ It was after I started levothyroxine. I have been using the Emerita
Progest cream one teaspoon am/pm (total 160mg day)and Vaginal Estriol Oil every other day. My breast were very sore and tender yesterday and I felt like I did when I was premenstrual.

I came home from work today and have brownish discharge. I called GYN and have an appointment tommorrow. I am really scared. The secretary said sometimes its just old blood.

Is it normal to have brown discharge after
menopause while using progesterone cream. I have felt wonderful since using it.

Thanks
Jun 20, 2012
 Brown Discharge 10 years menopause on Progesterone
by: Wray

Hi there Please don't be scared, it's not unusual to have a discharge, particularly as you're using oestrogen too. All oestrogens, even the mildest oestriol can cause cells to proliferate. It appears your lining has grown slightly over the time you've used it. It can increase anyway with the oestrone our fat cells make. And if it was brown this is definitely old blood. Often progesterone helps clean out the uterus. The Breast Tenderness is also due to oestrogen. One woman wrote in saying she had a full blown period after starting progesterone, she had been 12 years in Menopause. Nothing untoward was found. I'm pleased it's helped you, at least you're using a good amount! Take care Wray
Sep 22, 2012
 Bleeding after starting BHRT
by: Anonymous

Hi,

I was evaluated for BHRT and received 1 testosterone pellet of 50mg and daily troches at bedtime of 100mgs. No estrogen.

I have had the pellet for 10 days and have been on the troches for 7 days. I have started bleeding but not heavily, more like spotting.

Do I stop the progesterone? It's the weekend and I can't reach my dr. Thanks
Sep 23, 2012
 Bleeding after starting BHRT
by: Wray

Hi there Progesterone can upset the cycle when first starting it, making it either earlier or later than normal. It usually settles down within a cycle or two. But are you maybe in Peri-menopause, when cycles become very erratic anyway? I recommend 100-200mg per day progesterone, so you are using the lowest amount I've found works. It should also be used a minimum of twice a day too, as levels begin dropping after about 13 hours. There's more info on our page How to use progesterone cream. But you are also using testosterone too, so I don't believe it will be enough. Testosterone is also converted into oestrogen by the enzyme aromatase. It also causes visceral fat to increase too, see here and here. Plus it has a dark side in women, see here, here, here, here here, here, here, here and here. If the bleeding is just spotting then continue with the progesterone. If it becomes a full period then stop, and start again at ovulation. Troches are not the best Delivery system, as much of the progesterone is swallowed. Take care Wray
Sep 23, 2012
 Bleeding during use of progesterone
by: Anonymous

Thanks Wray for the quick response. I am now sorry I got the testosterone pellet and I won't get it again after reading your attachments. I find this entire subject so confusing. I am just trying to stop the mood swings and hot flashes, feel like myself again and get my body fat situation under control. I stopped having periods almost a year ago and have put on 30 lbs. I have never had a weight problem in my life. Dieting and exercise have no effect and I am not exaggerating. I run 3 days a weeks and eat 1200-1500 calories a day just to maintain. Any more calories and I gain. I never lose any weight. I am so frustrated.

Being that I don't have periods anymore and don't think I am ovulating should I just stop the progesterone for a week and restart? (bleeding has increased to more like a period). Thanks in advance for your help
Sep 23, 2012
 Bleeding during use of progesterone
by: Wray

Hi there It's not info I enjoy giving to someone who's been given testosterone. But feel there is too much evidence against it not to. Why it hasn't filtered down yet amazes me. According to this one paper here, the menopausal ovary is an androgen producing organ. I've just complied a page on libido for our web site. Some interesting findings too. One study found as women entered menopause there was a decline in sexual function, but there was no significant decline in circulating testosterone levels. Other studies found progesterone plays a significant role in libido. So if sexual function declines during peri-menopause, and progesterone has been dropping for years, it doesn't surprise me! The weight gain over the stomach is definitely related to hormones, particularly testosterone. Oestrogen simulates subcutaneous fat to proliferate, so we have to contend with both sorts of fat! So you are in Menopause, I didn't give you this page. Or the one we have on Oestrogen Dominance. Dieting and exercise won't affect the weight gain, you need to lower both the testosterone and the oestrogen. In spite of the myth we're fed that it's the decline in oestrogen which causes all the adverse symptoms we get, it's not. Progesterone begins dropping from about age 35, when we begin getting anovulatory cycles. These increase in frequency throughout peri-menopause, until we stop producing viable eggs at menopause. Then oestradiol declines, but our fat cells continue secreting oestrone, the menopause oestrogen, to the day we die. Unfortunately the cells do not secrete a counter balance of progesterone. As you haven't had a period for almost a year, this should be the only one you'll get. I've often found women who start progesterone shortly after entering menopause do get one, rarely two. There's still sufficient oestrogen to stimulate the lining to grow over that year. Using progesterone can often cause this bleed to occur. Because of this I don't think you should stop the progesterone. I don't find there is any need to take a break at all in menopause. In fact I didn't during the end stages of peri-menopause when I still had periods, as each time I did my symptoms came back. I've also found that 400mg/day, sometimes more, is needed to stop Hot Flushes. This will also help your mood swings too. Please use a progesterone which is absorbed well, the best are injections, suppositories or creams. Take care Wray
Nov 21, 2012
 Spotting after periods
by: OPtimistic

I am 38, I have a 8 year old daughter and trying to conceive. I had a miscarriage in January, did a D&C. My periods came back normally for 5 months, then in August my periods came and after the first 5 days i was just spotting and would not stop. My OBGYN put me on progesterone and the bleeding stopped at the end of September. My periods came back in on November 15 and now not stopping again. I am worried that I will not be able to get pregnant. My OBGYN will put me back on the pregeterone pills twice a day again. I am very worried though. Any advice?
Nov 24, 2012
 Spotting after periods
by: Wray

Hi there In all likelihood the 'progesterone' you were given was not, but a progestin. Please check the label, as obgyn's usually only give these, very rarely progesterone. Miscarriages are often caused by a lack of progesterone, low vitamin D too. We do have a page on Pregnancy you could look through. There are excellent videos at the end about the importance of vitamin D too. And another page here. Both Progesterone and Vitamin D are essential for ovulation, conception and a successful pregnancy. Both are critical to the health of the growing foetus too. Progesterone does stop bleeding, but often amounts of 400mg/day or more are needed. We have mrs info on our page about Menstruation. Take care Wray
Jan 26, 2013
 Endometriosis
by: Anonymous

Hi Wray,

I have been taking 200mg of progesterone daily (without a break) for 2 years to treat endometriosis. Feel great. I have not entered menopause, but i get no period due to the progesterone. except for last month suddenly I did. Are my receptors desensitized? If so how should I handle that? Do I still ovulate when taking progesterone daily? Many thanks for your thoughts.
Jan 27, 2013
 Endometriosis
by: Wray

Hi there I'm pleased the 200mg/day has helped, as I've usually found it has to be much higher. You say you are taking it, do you mean oral progesterone? Because if you do, I'm really surprised it's helped, as very little gets into the system. It's the least effective Delivery system. "The liver and gut region removed a mean of 96 per cent of the progesterone entering these tissues" see here. I'm also surprised it's stopped any bleeding, as again I've found levels much higher are needed. I live and learn! It would help to know your age, as you could be in Peri-menopause now, when progesterone levels are dropping. It could mean you need to use more. Using 200mg/day every day, if in a cream, or as a suppository or injection, would stop ovulation, it can act as a contraceptive, see here. Maybe you could come back to me with answers to my queries. Take care Wray
Jan 29, 2013
 Endometriosis Further Information
by: Anonymous

Thanks so much for responding Wray. Let me give more details. I am 43. I began taking 400mg of progesterone in year 1. (200 mg suppositories night, 200 cream in am) This stopped my period. This became too much (bloating, breast pain). So I weaned down to 200mg year 2. 100mg suppositories at night and 100 mg cream in am. No menses for a year until last week. Not sure why. Your thoughts are appreciated.
Jan 29, 2013
 Endometriosis Further Information
by: Wray

Hi there Then you could very well be in peri, this starts 5-10 years before Menopause. Daughters generally follow their mothers, so if you could find out when yours went into menopause, it will give you an idea of whether you're in peri now. Ah that explains why the progesterone worked, I also recommend 400mg/day to stop bleeding. The bloating and Breast Tenderness are actually caused by oestrogen, prolactin too. Plus a lack of iodine, but not progesterone. Oestrogen causes water retention, hence the bloating, see here, here, here and here. It's also an inflammatory hormone, it also stimulates Prolactin another inflammatory hormone, and substance P, a nociceptive neuropeptide causing pain and nausea. Progesterone is essential for Endometriosis which is caused by oxidative stress. But large amounts of antioxidants are needed to reverse it, although progesterone is one, but it's best to take others too. Particularly vitamin D, please have a test done. Something has disturbed the progesterone, many things can do this. Large meals and sugars drop levels, see here. Insulin drops levels too, see here. Dark winter days, this is often due to a drop in vitamin D over winter, as low vitamin D reduces the benefits of progesterone, see here, here and here. If progesterone drops, SHBG (sex hormone binding globulin) drops. With this drop testosterone rises, as all our oestrogen is converted from testosterone, this only means oestrogen rises too. But if bound to SHBG testosterone becomes inactive, progesterone raises levels of SHBG, see here. Continued below
Jan 29, 2013
 Endometriosis Further Information part 2
by: Wray

Hi there SHBG drops if sugars are eaten, even those found in all grains, legumes, processed milk and sweet starchy fruits and vegetables. Fructose, sucrose and glucose, reduce SHBG by 80, 50 and 40% respectively, see here. Thereby allowing testosterone to rise. It's best to avoid all the foods and sugars mentioned. Wine and beers contain carbs, so it's best to avoid those too. Plus alcohol affects hormone levels in women, see here and here. It decreases progesterone levels and increases androgen levels, both the total testosterone and free testosterone become higher. If you live in the northern hemisphere, you are now in winter, so this could well be the problem. Take care Wray
Feb 23, 2013
 bleeding
by: Anonymous

i have 35 days from my periods but light bleeding even taking progestrone. this cause not pregnancy?
Feb 23, 2013
 confused, please help
by: Michelle

I am 50 years old and still have monthly period. I had my hormones checked and I am estrogen dominent and low on Progestrone. Began the Progestrone cream on day 14, 50 MG/ML. The instruction is to apply daily from day 14 to 28. I applied 1ML at night and my symptoms got so bad that I got scared. My breasts were beyond tender, and my heart was beating out of my chest and I couldn't sleep at night. I found your site and learned that this has excited my estrogen and I should stick with it and increase it. So, I applied 1ML in the morning as well. I started a full blown period after 7 days of application. I continued applying the progestrone and I am not sure if I should. Please let me know if I should continue to apply or stop, and then begin applying 14 days from the first day of my period. Or should I continue applying through this bleeding until full two weeks?? Thank you
Feb 23, 2013
 Confused, please help
by: Michelle

I am sorry but also in addition to my previous question, I have found that I have two small fibroids. Would 100MG be sufficient???
Feb 24, 2013
 confused, please help
by: Wray

Hi Michelle Do you have a 28 day cycle, if so using it from day 14 is correct, not if it's longer or shorter. It should be used from ovulation to bleeding, i.e. for 14 days. Progesterone can upset the cycle when first using it, it does settle down in time. You are now in Peri-menopause when cycles do become erratic. No amount of progesterone will correct this, but it does help with adverse symptoms. Unfortunately the 50mg/day you used initially was too low, and did stimulate oestrogen. This is an excitatory, inflammatory hormone, hence the Breast Tenderness. Plus oestrogen causes prolongation of the QT interval, which results in palpitations, arrhythmia, Torsades de Pointes and sudden death. Whereas progesterone shortens the QT interval, see here, here, here, here, here and here. This is why more women get these problems than men, they have very little oestrogen, whereas we have a great deal more. I'm pleased you increased the amount, do you find it's helped? I find that's the minimum amount to have any real affect. I would suggest continuing with the progesterone through the bleeding. And it might be an idea to use it daily like this for 2-3 months. This will ensure excess oestrogen is suppressed and progesterone becomes dominant. Then when you feel stable you can begin following your cycle again. Please bear in mind these could become erratic soon, unless your mother went into Menopause in her late 50's. Daughters tend to follow the same pattern as their mothers. Continued below
Feb 24, 2013
 confused, please help Part 2
by: Wray

Hi Michelle Please have a vitamin D test done, there's evidence to show that Fibroids are caused by oxidative stress, in particular a lack of vitamin D. Taking it does shrink them, see here, here, here, here and here. Progesterone does help too, although I doubt 100mg/day will do much. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth and Birmingham Hospital. Blood levels should be 70-100ng/ml (175-250nmol/L) and not the 30ng/ml (75nmol/L) most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although recent research indicates it should be 10,000iu's per day, see here. Take care Wray
Feb 24, 2013
 bleeding
by: Wray

Hi there If you are still having light bleeding for 35 days, you are not using enough progesterone. Please consider increasing to 100-200mg/day, you might need more. There is further info on our page How to use progesterone cream and our Menstruation page. Take care Wray
Feb 25, 2013
 confused, please help
by: Michelle

thank you very much for your feedback. Increasing the progestrone definitely helped with my symptoms. I did get my Vitamin D level checked and although I was low in previous years, I have been able to increase the level. My question is by taking progestrone until I become progestrone dominant, what symptoms am I going to be facing??? I have heard that the symptoms are the same as estrogen dominance. When would one know to ease off???
Feb 26, 2013
 confused, please help
by: Wray

Hi Michelle I'm pleased the increase helped the symptoms. Please make sure your vitamin D level is high, between 70 to 100ng/ml. If you have your test results you could check. Yes the confusion between symptoms is extraordinary. The problem lies in getting adverse symptoms when using too little progesterone. So everyone thinks these are caused by progesterone, but they're not. It's the stimulating affect it has on oestrogen. So in fact all those symptoms are caused by oestrogen. I wouldn't begin easing off until at least 3 months suing the progesterone. But symptoms are the best guide, have they gone or not. When you do reduce do so by no more than 20mg per reduction, staying on that for a few days or a week or two before reducing again. There's more info on our page How to use progesterone cream. Take care Wray
Apr 27, 2013
 Bleeding
by: Anonymous

I started taking progesterone cream on day 10 because I missed it by 2 days and did not want to wait another month. After three days taking the progesterone, my period began again. I was wondering if this is normal. The package (Emerita Pro-Gest), said that if you start to bleed then stop the cream and count that as day 1. This is what I did, but I was wondering if this is normal.
Apr 28, 2013
 Bleeding
by: Wray

Hi there I'm not sure why you say you started the progesterone on day 10 because you missed it by two days. Are you saying you should have started it on day 8? If so why on day 8, do you have a 22 day cycle, ovulating on day 8? Progesterone does upset the cycle when first using it, making it earlier or later than normal. It's nothing to worry about it will settle down in time. We do have more info on our page How to use progesterone cream. Take care Wray
Jul 20, 2013
 in menopause and dry or fresh spotting
by: Dee

Hi
been on bio identicals for years memopause for two years.
at 55 I take 100 of projest. and the Vivelle dot patch 00.5 I was on 00.7 and was doing great until my dr. did an ultra sound and said the lining was too thick. put me down to the now oo.5 month later with dry old blood spots and occasional fresh, just drops then she told me to increase my projest by 100 (pill form) I was nervous and am just taking 50 more in the A.M. .. now this morning I see its like a real period.. was always light anyway but ... now what.. I get nervous buying the nappro because there are months on end when the supply is not in. don't want to get caught in that.. so what do you suggest.. I take 4000 of Vit. D. and Natureroid..(thyroid) I do have fibroids but always have. Otherwise I feel fantastic.
Jul 20, 2013
 in menopause and dry or fresh spotting
by: Wray

Hi Dee It doesn't surprise me your uterine lining is thick, this is what oestrogen is supposed to do. Progesterone does prevent hyperplasia, and is essential if it's endogenous oestrogen causing it. But I can't see any point in giving you progesterone to thin the lining, why not stop the cause, i.e. the oestrogen. There's more info on our HRT page. You say you feel fantastic, so it seems you don't need either hormone, besides the one is cancelling the other. But as you're taking oral progesterone, which is the least effective Delivery system, "The liver and gut region removed a mean of 96 per cent of the progesterone entering these tissues", see here, it's not doing a good job at countering the oestrogen if your lining is thick. We have had stock outs which generally last a week to 10 days, which I hope have now been solved as we've increased production. Fibroids are probably caused by a lack of vitamin D, they are certainly reduced by taking it, see here, here, here, here, here and here. I suggest you increase the dose to at least 10,000iu per day, see here. Take care Wray
Jul 22, 2013
 Your comments are great and thoughtful!
by: Tara

I first want to say how loving and educated your comments are for the people who ask you questions. This was so apparent for me that I am compelled to ask you a detailed question. Only because I seem to be stubborn and irritable about my doctors response to my care.
Jul 22, 2013
 Concern about bleeding while on 3 hormones.
by: Tara

I take Oral Progesterone 300 to 400 mg a day depending on what capsule I remember to take.
I suck on 1 to 2 lozenge compounded blend of 2mg estrogen/2mg testosterone depending on when I can remember to do it.
I have been doing this for 60 days now and bled for 20 days on my normal time for the cycle -lightly - then stopped bleeding for 7 days and now bleeding very lightly for 7 days - during my ovulation time. I am 'supposed' to start my period today, but its just tiny spotting with cramping and soreness.
I know I need to see the Dr. but I am hesitant to go without first becoming educated. So I am asking what your opinion is and reading as many texts as I can find.
Jul 23, 2013
 Concern about bleeding while on 3 hormones
by: Wray

Hi Tara Bless you for the kind words! I can't agree with giving any women more oestrogen, see our page on HRT for more info. And certainly not testosterone, see here, here, here, here here, here, here, here and here. Besides which it's a sure fire way to give a middle aged women a middle aged spread! See here and here. Oestrogen builds the lining, the withdrawal of progesterone causes us to bleed. By giving you oestrogen it just means it's continually building your lining. We do have more info on our page about Menstruation. Finally oral progesterone is the least effective Delivery system, "The liver and gut region removed a mean of 96 per cent of the progesterone entering these tissues", see here. So you are in effect getting very little progesterone. We have two more pages you could look through How to use progesterone cream and Peri-menopause. It's essential to use progesterone from ovulation for the full 14 days of the luteal phase, when bleeding should start. The luteal phase is always, in all women, 12-14 days before bleeding, irrespective of the cycle length. It's also essential to use the same amount each day and not vary it. This will confuse the uterus and moods no end! Take care Wray
Feb 06, 2014
 Not sure what to do
by: MerryKate

I started on NatPro about a month ago, after reading Suzanne Somers' book on perimenopause. It was a life-saver for me...I've had a terrible struggle with PMS my whole adult life, which only intensified with perimenopause (6 years of cyclical misery). After 28 days on the NatPro I took a week off, per the instructions for menopause (since I hadn't had a period in 3.5 months, I couldn't go by my cycle). 4 days after stopping the NatPro, I started spotting, very lightly, with no cramps. Should I start using the cream again on schedule, or wait until any spotting has stopped?
Feb 10, 2014
 No withdrawal bleed!
by: Anonymous

I have been using natural progesterone to have a monthly withdrawal bleed for several months. (Off and on for years) It has always worked great for me. The past two months I have applied 2 times a day for about 2weeks and no period. No withdrawal bleed at all! I have gone over 60 days with no period. Sore breasts but negative pregnancy tests. No cramps or pain. I have always had irregular cycles but why would the cream just stop working?
Apr 16, 2014
 estradiol 2mg and progesterone 400mg for gettin pregnant
by: Anonymous

I am having pcos and want to get pregnant. I was for 4 months on contraceptive to regularise my periods My doctor gave me estradiol 2mg to start on 5th day after periods starts and progesterone 400 mg after 16 days from when the period started and do the same for three months andif I don't get pregnant in these three months they will do a xray to rule out why am I not getting pregnant please help is this the right prescription....waiting eagerly for your answer
Jun 17, 2014
 bleeding every 2 weeks on Oral Progestrone
by: BevM

Hi,

I have been on progesterone for 2 years - I am 52. I had a failed oblation surgery and the started bio-identical therapy -which was just natural progesterone. That works for a few months great 50 mg. - light bleeding - normal period every 28 days - then started going back to every 2 weeks. Kept upping my dose -to 200 but did not regulate. Switched drs - she put me back on 200 mg (regular oral microcrystal progestrone) from pharmacy and has not changed. Still get period every 16 days - very tired of living like this! I only have 7 days of the month when I'm not. Can I try doubling my dose 200 in am and 200 at night? Or should I swtich to a cream - I'm ready to just have a hyster. which my last 2 female doctors recommended - but I don't have endo,polps or any other issues (I've had all the tests done) and bloodwork - I was anemic, low vitamin d and do take vitamins - but no change in my horrible cycle.
Jun 19, 2014
 Get tested
by: MerryKate

BevM -

Before you start upping your dosage, I'd encourage you to get a tests of your hormone levels. It sounds like the balance between your estrogen and progesterone levels is already out of whack, and if you add more of either hormone to the mix, it could make things worse. If your current doctor isn't doing a good job, find one who really understands how these things work. You deserve good healthcare...heaven knows you pay enough for it. ;)
Sep 03, 2014
 need some guidance-just got my period
by: JC

Hello,
I have been using Natpro for just over one year after not having my period for 2 years- I am 56 years old. I started the progesterone on the advice of my MD for treatment for prolactoma and fibroids. My hormone levels when I started Natpro were estogen 5.0 and progesterone was 0.1 and prolactin was 103. (I had very bad side effects to the prolactoma medication called parlodel, which did lower the prolactin initially, but I could not stay on it.) My MD also suggested taking a DHEA supplement as my DHEA level was very low.
After a couple of months of being just on the natpro (stopped the Parlodel) I started to feel less tired and achy and less depressed. 5 months ago, I got my period, again it had been over two years since I had it last. It was a normal period for me, some cramping and pain, but it lasted about 6 days and there was no 'flooding'. So I talked myself into not panicking and did a little research on the web. Got the whole range of answers from it is OK...to uterine cancer! I calmed myself down and now just today after 5 months I got my period again. Now I am really scared. The only change I can think of is that 5 months ago, I started using the Natpro cream vaginally to combat dryness and again, 2 weeks ago I thought I would try it again for the dryness and now I am in this situation with all these questions. Any information will be most helpful. My vitamin D levels are 83 ( I take a supplement). My prolactin, although still high at 40, has at least come down a lot. I have not had my estogen or progestrone retested yet. Peace.
Sep 04, 2014
 Periods again...
by: MerryKate

Hi JC,

Are you using the Natural Progesterone cream on a daily basis? It can cause your period to resume if it's used cyclically, even in women who have gone through menopause. It's the trade-off you get for having all the benefits of progesterone. If it concerns you, see your doctor.
Sep 04, 2014
 menopause, increased progesterone, bleeding
by: jean

Hi, I've been on BHRT bi-est 1.5 mg and progesterone 50 mg morning and 100 mg at night for about nine months. My night sweats were severe and I began to have bad anxiety. All of that is in the past, but I've been questioning the need for estrogen at all, so I decided to go off of it and have increased my progesterone at night to 200 mg which has helped sleep even more. But, I did get a full blown period this week (I am two years into menopause, 50 years old). Is that because of the increase of progesterone clearing me out so to speak? And is this a temporary thing as I acclimate to the new level of progesterone?
Thanks,
Jean
Oct 10, 2014
 Please help
by: Anonymous

I am 47 and in menopause. Hot flashes, dryness, no energy, weight gain, and absolutely no sex drive! My thyroid was low but not enough to be medicated. Doctor recommended taking metagenics i3c, Thyrosol, and b complex supplements. I was depleted in vitamin D, I'm am taking 50,000 IUs once a week. . I recently started hormone therapy in July using estrogen pellets along with progestrone pills(100mg) I missed a progesterone pill and I started my period. I haven't had a period in a year. . The doctor told me to stop taking it for two weeks and schedule an ultrasound next week. I am having major mood swings and feel the pellets are not helping at all. I can't afford to spend hundreds of dollars on the pellets and progestrone pills for it not to work. The rapid weight gain is almost too much too handle. Doctor gave me a water pill but it hasn't helped much. I hope I'm making enough sense to give you information as to what I need to do. Please help. I want to feel normal.
Oct 12, 2014
 Some quick answers
by: MerryKate

Jean, progesterone is the chemical that regulates periods, and it's the one that drops off to nearly nothing when you enter menopause. As a result, if you add progesterone to your HRT you will get periods. It's not a one-time thing - it will be an ongoing cycle in your life. On the good side, it helps protect your system from breast and ovarian cancer (as opposed to taking estrogen alone).

Anonymous, it can take a while for your hormones to even out after starting HRT – 3 to 6 months is not uncommon. The symptoms you listed are indicative of an estrogen and progesterone imbalance, so give the HRT some time to work. If the mood swings are overwhelming, talk to your doctor about adding an antidepressant until your hormones adjust. There is scientific evidence that they help even out the mood swings of menopause. I personally prefer St. John's Wort since it has far less side-effects than the synthetics and available over the counter (and therefore much less expensive).
Nov 25, 2014
 HRT-spotting & bleeding
by: Kathy

Hi
I am 58 years old and 3 months ago went on Prometrium -200mg at bed, and estrogel-2.5 g daily, in the morning.
My sleeping prior to this & night sweats were unbearable.
So I am very happy and relieved this has helped with both of these issues.
However I am concerned because the spotting is increasing, and I do not know if this is normal, and part of my body adjusting or if I need to increase or decrease the dosage or just carry on for the next 5 months as is. We are travelling therefore my Dr. is not here for me to consult.
Thank you I do appreciate any advise you can provide.
Dec 10, 2014
 question about breakthrough bleeding
by: Anonymous

Hi,

I've recently started using progesterone cream (actually rx-d through a compounding pharmacy by my doctor). Reading some of these comments makes me wonder if she's prescribed too little. I take different amounts through my cycle. But also, since taking it I'm having no period or breakthrough bleeding while using it (I've been using it about 4 months).

If I skip a period should I still use the cream just as if I were having a period? And should I continue using it if I'm having breakthrough bleeding or just stop and start another cycle? I'm 50 years old but until starting the cream my periods were regular (about every 28 days).
Jan 14, 2015
 Just started bio-identical progesterone and am confused
by: Sue

Hi

I just started bio-identical progesterone. I'm 48 and peri- menopausal. I started bleeding a lot day two snd stopped using the cream. Do I wait 10 days ( that's what I was prescribed), or start up again? The bleeding has stopped. Then my script said "take 10 days after start of period." Will I get a period right after I stop? Do I then do 10 on 10 off since I no longer have a normal period?
Feb 05, 2015
 Bleeding using progesterone
by: Anonymous

Hi there..I have been taking Pro Gest for about 3 weeks now. I just finished my period a few days ago (which was lighter and not as much clotting) but now today I have started bleeding again. I continued to apply the cream throughout my cycle. I have no idea how much to squeeze out of the Pro Gest bottle every morning and night. Is this normal? Am I taking too much or too little based on my bleeding?
Feb 17, 2015
 brown to red vaginal discharge while taking progesterone
by: Anonymous

Good day i have PCOS and been prescribed of taking 14 pills of progesterone for 14 days. I had brown vaginal discharge and now on my 7th pill i had red discharge like am having menstruation what should i do? is it normal?
Mar 18, 2015
 spotting on progesterone
by: Anonymous

Hello, last night for the very first time ever I started to spot....I am mid cycle and thought maybe I was starting my period early so didn't take mt 60 mg last night, but this morning it appears to have stopped. Problem is that my symptoms are up now since I missed and wondered if I needed to take 30 mg (2clicks) this morning or just wait and take as usual tonight. I am 29 yrs old with excessive estrogen levels and been on crew for 4 months or so.
Jul 19, 2015
 break through bleeding
by: Anonymous

I am menopausal, no periods for over 2yrs. Am taking 200mg touches of progesterone and 0.18 oestrodol, which I am now only taking 1\4 per day. I just went to a new distributed for the touches and now having monthly break through bleeds. Do I need to stop touches when I bleed or continue. And why am I having the bleeds? Should I reduce the oestrogen? I reduced the oestrogen as I get tender breasts and headaches and the small dose is currently managing symptoms. Could I take progesterone only for my symptoms? Thanks for any advice
Aug 28, 2015
 Period every other week
by: Kriss

Hi, I'm 38 & have always had regular periods. Back in April I complained to my gyno about my period....they would last 7 days. She prescribed progesterone which I took for 30 days. Once I stopped taking it, I get my period every other week. Help!
Oct 24, 2015
 Bleeding when taking progesterone
by: Anonymous

I usually have normal cycles. However, I was on the Mirena IUD for a year and bled almost the entire time. I finally had it removed. I didn't know if the cause of the bleeding was irritation from the IUD itself or from the synthetic progesterone that it secretes. However, I'm now in perimenopause with still regular periods and have been getting much worse premenstrual insomnia over the last two years. I'd read that it's likely progesterone deficiency (I'm an M.D. -- it seems like progesterone decreases earlier than estrogen does in perimenopause). Anyway, I'd also recently read the concerns of synthetic progesterones so I started taking prometrium 100 mg on days 14-28 of my cycle. I'm only in my second month. During the first, it made my period come 3 days early, so I stopped taking the pill when it started, and my period went away for a few days and re-started again at its usual time. This month, I took progesterone beginning on day 14, and I started to bleed again after only 3 days this time. I quit taking it three days later since the bleeding didn't let up, and after three more days, I'm still bleeding though it's lessening. The progesterone has to be causing the bleeding. Is the dose too high? Is it just the way my body (and it seems several on this post as well as a minority of people who go on Mirena) responds to progesterone (i.e., bleeding)? It seems like this response to progesterone (bleeding) is something that a small subpopulation gets. When on birth control pills, I also had to take the Loestrin to avoid heavy periods and feeling overly emotional. After having my kids and failing with the Mirena, my doctor thought I might now be OK with regular OCP doses (as my hormones were now in decline) so she put me on Seasonique for 6 months (you only have a period every 3 months on this), and after the 2nd 3 month period I passed a uterine decidual cast (not fun). The only instances I could find in the literature of people passing these were when they were on DepoProvera (long-acting progesterones). I'd love to get your insight. Should I try a lower dose or is progesterone just not for me and why does it make me bleed?
Jan 17, 2016
 Hi
by: Anonymous

Hi I am 54 years old and have not had my period for about 4 months . .I started Natpro morning and night 5days ago about 1/2 tsp in morning and same before bed .. This morning I woke up to spotting .. Not sure if I should continue or if I'm not putting enough on .. And should I continue through the whole month without stopping .. Thank you
Feb 22, 2016
 Spotting first week using natural progesterone cream
by: Nicki

I am 37 years old. My periods have always been like clockwork every 25-28 days. A few moths ago they started coming on and off every two weeks with other symptoms....constant tender breast, night sweats, headaches. I started using the cream recently to see if I get relief and within a few days of using it I have been spotting ( sometimes light spotting sometimes heavier but nothing more needed than a panty liner). Is this normal? Everything online refers to cervical cancer and I'm freaking out. Could my body respond that quickly to a natural cream and cause this spotting?
Feb 23, 2016
 Spotting first week using natural progesterone cream
by: Joy

Hi Nicki

First of all please take a deep breath and relax. Secondly, I would be very careful what websites, blogs and articles you read, the website is riddled with misinformation by misguided people. It is quite clear that what you are experiencing and starting to go through is the dreaded Peri-Menopause. It can be a difficult for some women, but with the help of the correct use of progesterone, it will make is so much easier. P-M usually starts are around 37, so you are bang on there. On top of that you are suffering from Estrogen Dominance, so where does cervical cancer fit in?? What you are experiencing is quite normal and is the natural process of a women’s life!

Progesterone therapy is not an overnight fix, it can take anything from 2-6 months before positive signs are felt, it can take longer, it is all dependant on how much excess estrogen you have in your body and how severe your symptoms are. Progesterone therapy will not work if it is not used correctly, taking into account that the correct progesterone concentration must be used. The How to use Progesterone Cream page will help you greatly. I have no idea what cream you are using or how much, this again is very important. Usually when in P-M, nothing less than 200mg per day is need, every day with no breaks at all.

Another thing that is so very important is Vitamin D3 and its co-factors. Do you know what your level is as a deficiency reduces the benefits of progesterone, it is also vital for every functioning cell in our bodies.

Please relax, read the following pages and take it from there.

Peri-Menopause - https://www.progesteronetherapy.com/peri-menopause.html#axzz2m6SW8qc0
Estrogen Dominance - https://www.progesteronetherapy.com/estrogen-dominance.html#axzz3fNOYF0aj
How to use Progesterone Cream - https://www.progesteronetherapy.com/how-to-use-progesterone-cream.html#axzz2mglwLvMr
Progesterone Cream - http://www.progesterone-info.com/natpro-progesterone-cream.html
Vitamin D3 - http://www.progesterone-info.com/benefits-of-vitamin-d.html
Mar 25, 2016
 need advice
by: Anonymous

I have simple hyperplasia without atypia. I was started on progesterone pills 100mg daily for 20 days and then 10 days off.. I have breakthrough bleeding.Should I stop the pills and let the bleeding continue or should I continue the pills while bleeding. Thanks
Mar 28, 2016
 Tender breast whilst using progesterone cream
by: Judy Browne

I have been using progesterone cream for 3 weeks and my breast are tender like I am about to have my period. Can I get pregnant even though I am menopausal. Regards Judy
Mar 29, 2016
 Tender breast whilst using progesterone cream
by: Joy

Hi Judy

If you have a monthly period there is always a chance of falling pregnant. One can safely say that a missed period for 12 months puts one in Menopause when conceiving is highly unlikely.

Your tender breasts most probably are due to not enough progesterone being used or you could be deficient in iodine, have you had that tested?

Also what is your Vitamin D3 level, a deficiency reduces the benefits of progesterone.

Please read the following pages on the websites:

How to use Progesterone Cream - https://www.progesteronetherapy.com/how-to-use-progesterone-cream
Estrogen Dominance - https://www.progesteronetherapy.com/estrogen-dominance
Menopause - https://www.progesteronetherapy.com/menopause.html#axzz2og853i1N
Vitamin D3 - http://www.progesterone-info.com/benefits-of-vitamin-d
Aug 06, 2016
 Daily progesterone and 14 day cycles
by: Stacy

I hope someone can offer some insight. I'm 31, pcos and have never really had a natural unmedicated cycle. I started seeing a HRT doctor in may and she put me on metformin (2000mg daily), progesterone (250mg daily).
Since the week I started the medications I got my first cycle... but since that first cycle for the past 3 months I have a period every 14 days. Doctor told me it can take a year to regulate, but I'm not convinced I should keep at it. A year of bimonthly bleeding is an awful lot to deal with.
Sep 11, 2016
 bleed don't stop
by: ann

I have been using the cream and still bleeding heavy and blood clots I have been on the cream for 3 weeks
P.S. I don't know what to do my sex life is going down hill the reason. I got on the cream I had been on my dots for two months straight please help me
Nov 06, 2016
 BHRT
by: Anonymous

Post menopausal. Pellets have changed my life. The only down fall is the break through bleeding and return of cycle. Dr. upped oral progesterone to 200mg at bedtime. I sleep great, but bleeding is almost a daily occurrence. I am bleeding still after 4 months pellets insertion but having hot flashes, fuzzy thinking again.
Nov 07, 2016
 bleed don't stop
by: Joy

Hi Ann

Using Natpro Progesterone Cream for 3 weeks is certainly not going to produce anything. It should be used for 2-6 months with no breaks at all until the cycle returns to normal and ALL adverse Estrogen Dominance symptoms have cleared. Please consider the HEAVY/CONTINUAL BLEEDING PROTOCOL it must be followed exactly as stated otherwise it will not work.


•Natpro - 400mg to 500mg/per day
•N-Acetyl-Cysteine (NAC) - 2000mg/per day
•Taurine - 2000mg/per day
•Vitamin D3 - 5000iu's/per day more if Vitamin D3 level is low. A deficiency reduces the benefits of progesterone
•Bioflavanoids - 1000mg/per day


Please read these pages and the references:

How to use Progesterone Cream - www.progesteronetherapy.com/how-to-use-progesterone-cream
Estrogen Dominance - https://www.progesteronetherapy.com/estrogen-dominance
Menstrual Cycle - https://www.progesteronetherapy.com/menstruation-cycle.html#axzz3B7Rwrbwc
Progesterone Cream - http://edge.affiliateshop.com/public/AIDLink?AID=101365&BID=11417
Vitamin D3 - http://www.progesterone-info.com/benefits-of-vitamin-d
Magnesium - http://www.progesterone-info.com/magnesium.html
Nov 08, 2016
 BHRT
by: Joy

Oh yes that is what usually happens. One feels a million dollars when first using the pellets, then all hell breaks loose. Any kind of oral progesterone is not the best delivery method either and 96% get destroyed by the gut and liver- see here https://www.progesteronetherapy.com/progesterone-application-methods.html#axzz2cxfbj1W9. You are battling with Estrogen Dominance. Please read my reply to Ann above.
Dec 16, 2016
 UD
by: Anonymous

I am experiencing sometimes brownish, sometimes pinkish and this morning and brownish red discharge. I am 7 weeks pregnant and I'm on endometrin 100mg 2x daily. Still feeling nauseous and having full feeling breasts, but get abdominal cramps in between and lower back pain. Is anyone else going through this. It is my first time using endometrin and having these symptoms. I have a daughter and didn't go through these things. Could it be the endometrin causing this even tho I was spotting brownish and sometimes pinkish but very little before. Can someone please help.
Jan 21, 2017
 Thickened endometrium (three months ago)
by: Anonymous

I am 25 and had abnormal bleeding for days I was advised to take an ultrasound scan which showed thickened endometrium. Therefore, I was advised to take meprate (progestogen) tablets for 21 days each month for three months.

I'm done with the course and the endometrium thickness was about 5mm 15days ago. However, my periods started after two days of stopping the medicine and I have been bleeding for last 7days. The flow isn't heavy but cannot just call it spotting either.

It doesn't seem like it's gonna stop. Is it the effect of meprate ? How long will take for my periods to stop?

Also, my blood tests for thyroid is normal. So there is no other causes such as pcos or etc.

What do I do so that my periods stop and regularize? I don't have to on pills again. Please advise.
Jan 27, 2017
 Breakthrough bleeding
by: ElleC831

I am using progesterone cream for estrogen dominance. I was feeling a benefit and read that it's more powerful when applied vaginally, I inserted 50 mg and applied the other 50 to my skin. Later into the next morning I started spotting and it hasn't stopped. It's been week. It's as though I'm having a light period without any of the side effects. I've continued to use the dose on my skin but I am afraid to use it vaginally anymore. Is this normal? I am not pregnant,I had tubal ligation 11 years ago.
Jan 30, 2017
 Going on 10 days
by: ElleC831

Upon the start of the 100 mg progesterone cream, I have now been bleeding for 10 days. I have read that this can be due to the build up of the lining over time on account of aggressive estrogen. Today feels like a period, but it would be a week early. I just can't convince myself that this is normal.
Feb 01, 2017
 Breakthrough Bleeing
by: Joy

Hi ElleC831

I am pleased that you are seeing the benefits. The vagina is the best place to insert progesterone cream. Using 100mg per day of a 3.33% cream may not be enough for you. It can take 2-6 months for the body to adjust, I am not concerned about the bleeding. Please continue inserting in the vagina at night but it must be used in the morning as well. What is your Vitamin D3 level, a deficiency reduces the benefits of progesterone. Progesterone must be used twice a day, morning and again at night as levels start to drop after 12/13 hours.

Please read these pages and references:

How to use Progesterone Cream
https://www.progesteronetherapy.com/how-to-use-progesterone-cream
Estrogen Dominance
https://www.progesteronetherapy.com/estrogen-dominance
Vitamin D3
http://www.progesterone-info.com/benefits-of-vitamin-d
Magnesium
http://www.progesterone-info.com/magnesium.html
Apr 30, 2017
 Bleeding and Spotting During Progesterone
by: DeeDee

NP ran tests. My progesterone and Vitamin D were low.

I am 31 and currently trying to conceive. I've been taking 200 mg orally of prometrium and 5k of vitamin D for 2 months. I have been told to take it all month.

Period was late 10 days but went to NP who said body would catch up. Then 8 days after it had ended I've started at first spotting and then bleeding.

It's been 10 days of this. Is it breakthrough bleeding?

It happens mostly after BM in the morning and continues into to the afternoon.

I've had internal ultrasounds, pap smears and stds checked with all results normal earlier this year so it might not be gyno related but hormonal.

Please help.
May 02, 2017
 Bleeding and Spotting During Progesterone
by: Joy

Hi DeeDee

If your progesterone and Vitamin D3 levels are low you could experience difficulties in falling pregnant. Oral progesterone is not the best delivery method and 96% gets destroyed by the gut and liver. Please consider using a good quality progesterone cream. When first using progesterone one may experience bleeding and spotting while the body adjusts.

Please read the 'Pregnancy', 'Estrogen Dominance' and 'How to use Progesterone cream' pages as well as the references.

A low vitamin D3 level reduces the benefits of progesterone and is vital to the unborn child and pregnant mother. Stress destroys both progesterone and vitamin D3 levels not to mention other vital nutrients, more needs to be taken during stress-full times.

Hope this helps.

How to use Progesterone Cream - https://www.progesteronetherapy.com/how-to-use-progesterone-cream.html#axzz2mglwLvMr

Estrogen Dominance - https://www.progesteronetherapy.com/estrogen-dominance.html#axzz3fNOYF0aj

Pregnancy - https://www.progesteronetherapy.com/faq-conception.html#axzz3iLt8Z7fS

Dr Kittie Dalton - https://www.progesteronetherapy.com/progesterone-and-conception.html#axzz2sId3OmqY

Delivery Method - https://www.progesteronetherapy.com/progesterone-application-methods.html#axzz2cxfbj1W9"

Vitamin D3 - http://www.progesterone-info.com/benefits-of-vitamin-d.html

Magnesium - http://www.progesterone-info.com/magnesium.html

Stress - https://www.progesteronetherapy.com/definition-of-stress.html#axzz2og853i1N
May 26, 2017
 Brown bleeding using progesterone cream
by: Tracy

Hi, I started using a progesterone cream by Puritan's Pride. I wanted to use it because my breasts were becoming very sore near that time of the month, I swelled up, and my flow was getting heavier and noticeably more painful. This started after the birth of our daughter. When I had my son, my cramps disappeared, but the flow was definitely heavier (and by heavier, I mean normal, it used to be what most women would call a light flow). Oh, and very irritable. I started prior to my last period. I use roughly 1/2 tsp twice daily.

Well, I noticed some changes. The cramps did not come. I started spotting, then bleeding, brown blood. The change I was not expecting was that my tummy went down, and not hard. It used to feel like I had a mini ball in there when I bent over. Is it possible my uterus did not fully go back to its normal size? I thought that breastfeeding was supposed to help shrink it back into place. My tummy was not big after I had my son. I had an emergency C-section, and my husband said they cleaned out the uterus, so no placental remains. If my uterus is indeed shrinking, and to me the bleeding would make sense, would this be from the progesterone?

Thanks.
Jul 28, 2017
 When to start progesterone cream
by: Anonymous

I bleed heavily for two weeks at a time and spotting in between. I have no idea when my cycle is or how many days it lasts. When should I start the cream and how many consecutive days should it be used? And how many days off?
Sep 18, 2017
 Northeisterone and natural progesterone
by: Anonymous

Hi, I am taking 3 times 5mg Norethisterone a day, 21 days on and 7 off and also using 1/4 tsp 'Serenity' natural progesterone daily.
The NHS doctor in UK told me to take Norethisterone to try and regulate my prolonged bleeding following three months of no bleed - diagnosed as premenopausal irregularities.
The makers of Serenity cream have told me to take the cream for two months while still taking Norethisterone.

The trouble is, I had a bleed in my week off of Norethisterone, but then 7 days after starting it again, I bled dry red blood one day followed by brown blood the next. Serentiy makers suggested it could just be old blood being shed, which it looked like, but I have continued to spot on and off now for nearly a week later with very pale pinky brown discharge.

Is this normal or should I go back to the NHS doctor (who is not very helpful at all!)
Sep 18, 2017
 Norethindrone and natural progesterone
by: Joy

I read all too often about doctors and NHS not being very helpful, this is so sad. Why are they in this profession then?

Sadly you have not been advised correctly by either the NHS or by Serenity. Norethindrone is not a natural progesterone it is progestin, a drug and all drug based HRT’s and Contraceptives have a potential to cause harm. So you have been pretty much misguided with that. To be told to use 1/4 tsp of the cream incorrect. Nothing less than 100mg/3ml is needed per day, more if symptoms are severe. For example if you are battling with heavy bleeding you need to use between 400-500mg per day. For a start, a war is now taking place between norethindrone and progesterone made worse by using way too little progesterone. You will continue to experience problems unless you increase the amount of progesterone and stop the norethindrone. Please read up on the side effects of norethindrone on the contraceptives page. A good organic progesterone cream such as Natpro will help you especially if you are in Peri-Menopause.

Were you advised about the importance of Vitamin D3? A deficiency reduces the benefits of progesterone. Vital co-factors are needed.

Please read these pages below and well as the references papers as they will explain exactly what is needed and how progesterone works.

How to use Progesterone Cream - https://www.progesteronetherapy.com/how-to-use-progesterone-cream

Estrogen Dominance - https://www.progesteronetherapy.com/estrogen-dominance

Vitamin D3 - http://www.progesterone-info.com/benefits-of-vitamin-d-cholecalciferol.html

Magnesium – http://www.progesterone-info.com/magnesium.html

Contraceptives – https://www.progesteronetherapy.com/contraceptives.html#axzz4AIV9TmFR

Peri-Menopause - https://www.progesteronetherapy.com/peri-menopause.html#axzz2m6SW8qc0

Menopause - https://www.progesteronetherapy.com/menopause.html#axzz2og853i1N
Dec 20, 2017
 Severe sciatic pain even after mega dosing progesterone for 4 straight months
by: Melissa

Hello, I am at my wits end because I have low progesterone and have been taking 800 mg for three straight months with no relief of my sciatic pain.

This last month, I started taking 1400 mg and my pain seems to have gotten worse at times. When I first apply the cream, it feels much better, but this relief is short lived. I took a blood test a few weeks ago and found my progesterone to estradiol ratio to be 15, though I believe it should be over 200.

How much longer am I going to suffer with this pain? I thought that I would be feeling better by now.
Jul 06, 2018
 spotting while on vitex and progesterone
by: Cheryl

Hi,
I am 42 and have had 6 healthy pregnancies. I am now having trouble concieving my seventh. I have a 29 day cycle, but always spot very lightly not enough even for a pad, 4 days before day one of my cycle. I suspect a luteal phase defect. I have been taking vitex and progesterone creme for 3 months. I am only taking 1/2 tsp of progonol cream daily. Is this sufficient to fix luteal phase defect? Should I continue cream even when I spot. Am I just too old to have any more?

Thank you for your help
Jul 09, 2018
 spotting while on vitex and progesterone
by: Joy

Hi Cheryl

The typical 20-40mg per day that is recommended does not raise levels to that found in the luteal phase, between 100-200mg is needed. Use the cream every day until your cycle becomes normal, once it does, use at your luteal phase. Please read How to use Progesterone Cream.

You are also in Peri-Menopause, cycles tend to become erratic at this time. The correct use of progesterone should help you. You might also like to read the Pregnancy page.

Vitamin D3 is very important as a deficiency reduces the benefits of progesterone, optimal range is between 70-100ng/mL. Nothing less than 5,000iu's is needed daily. Co-factors are needed when taking D3, magnesium and vitamin K2 with no soy are the important ones.
May 20, 2019
 premenopausal
by: Anonymous

Hi, I'm 52 years old and have been having pre-menopausal symptoms and also have hypothyroid. Dr put me on meds for thyroid and then had bioT plus on progesterone 200mg every night but it's been more than three weeks and I haven't stopped bleeding/spotting (before it was maybe every six to eight weeks periods and for only 1-3 days).

I'm tired of this and thinking of maybe stop taking progesterone completely? Would that stop the bleeding/spotting? It's very uncomfortable, I'm bloated, don't feel hungry and have headaches and body ache all the time for the last couple of weeks.

Please let me know should I stop or yank up the dose? thanks in advance!
May 21, 2019
 Premenopausal
by: Joy

Hi there

You are suffering from Estrogen Dominance. I suggest that you increase the amount of progesterone but it should never be used less than twice a day. Half the amount in the morning and the other half at night. This will help to keep progesterone levels stable. Use every day with no breaks. Please read the How to use Progesterone Cream page. Progesterone therapy is not an overnight fix, it can take 2 to 6 months before one notices a difference.

You are also in Peri-Menopause which can be a terrible time for most women.

Vitamin D3 is very important as a deficiency reduces the benefits of progesterone, optimal range is between 70-100ng/mL. Nothing less than 5,000iu's is needed daily. Co-factors are needed when taking D3, magnesium and vitamin K2 with no soy are the important ones.
May 22, 2019
 200 mg Progesterone is too high
by: Jenn, MD, PhD

Hi, I'm responding to the commenter from May 20, 2019.

200 mg is a high dose of progesterone. 100 mg made me bleed constantly (so did the Mirena progesterone-secreting IUD). Some of us are just more sensitive to hormones than others. For lower doses than 100 mg (lowest dose of Prometrium which is a regular prescription), you'll need your doctor to order it from a compounding pharmacy. I re-started with a 50 mg pill, taken every evening with meals to improve absorption (fat soluble). That worked great for a few years. I then started to notice some of the troubling perimenopausal symptoms return (premenstrual insomnia was my most annoying one). We increased it to 75 mg/day, and I'm back to no symptoms. My Vit D3 did decrease over this time so I'm not sure if this is the reason it became less effective or if it's just progression towards menopause.

I would give your body a short break from progesterone until you are no longer bleeding plus a week or so. Then, you could try the 100 mg Prometrium or a lower dose from a compounding pharmacy. If 100 mg makes you bleed, you need a lower dose. Figure out what your body needs. I take it every day, some only take it for 14 days of the month. Most people take it at night/dinner and avoid taking it in the morning because it can decrease your cortisol levels and make some people sleepy. I never noticed this issue myself but have started taking it mostly in the evening at the behest of my doctor.

Best of luck,
Jenn
Dec 09, 2022
 Progesterone cream and bleeding
by: Liv

Hello,

I am 39 with history of Fibroids. My periods are long and heavy with clots. Also TTC right now. My Pg/E2 ratio is 62. My doctor thought that it was low and suggested a progesterone cream.

My cycles are usually very stable with no breakthrough bleeding but since I started PG cream 4 days ago, I started bleeding in the middle of my cycle. This happened to me only twice in the past when I used Vitex. With Vitex, I bled so much that I almost died!

No one, including my doctor, seem to understand why Progesterone makes me bleed so much.

I also take NAC and Vit D regularly.

Any help will be greatly appreciated! Thank you.
Dec 11, 2022
 bleeding
by: Jenn

I used to bleed with progesterone as well. I had the Mirena IUD put in (secretes progesterone), and I bled the entire time. I gave up on it after a year. Then, when I started perimenopause, I began to have premenstrual insomnia. I was prescribed 100 mg progesterone at first, but it made me bleed again. We went down to 50 mg, and this dose worked great to stop the premenstrual symptoms without any bleeding for several years. As I aged, I had to increase the progesterone to 75 mg and a few years later (recently) to 100 mg. This dose no longer makes me bleed because I have much lower levels of progesterone in my system now and am pretty close to menopause (though still menstruating). My bleeding was never life-threatening or super heavy like yours so we may have slightly different issues, but my experience was similar in terms of it causing me to bleed (just different in the amounts, I guess).
Dec 11, 2022
 Progesterone Cream and Bleeding
by: Joy

Hi Liv

There is no need for me to repeat what has already been mentioned by Wray and myself. Please read all the links regarding Fibroids, Estrogen Dominance, Peri-Menopause (PM) and How to use Progesterone Cream. Wray discusses heavy bleeding in detail. Your cycle will become irregular as you are now in PM. If you are TTC you must try to work towards getting your cycle regular if at all possible. This is difficult during PM. You might like to read the page of pregnancy, see here.

If your ratio is correct at 63 that is way off, it should be around 600:1, see here. You need a lot more progesterone to get your level up. I am not a believer in Vitex as it is estrogenic. However, if it works for some, then that is great.

You don't state how long you were using progesterone for and how much. This is important as explained in the links mentioned on this website.
Dec 11, 2022
 Bleeding
by: Joy

Hi Jenn

The Mirena does not contact natural progesterone, it contains progestin which is synthetic, see here and please read up on the side effects. Many get confused as they have not been informed correctly. Between 100-200mg 3% natural progesterone is usually needed, more if symptoms are severe. As you are in Peri-Menopause (link) given on this thread, you really should use it every day with no breaks at all. It takes 2-6 months for the body to adjust to progesterone therapy, possibly longer. It all depends on how severe symptoms are.

A missed period for 12 months puts on in Menopause.

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