Bio-identical Hormone Therapy

by Marsha
(Naples, FL)

I'm on bio-identical hormone therapy (compounded cream). The results of my recent blood test showed that my body was not absorbing progesterone via the cream, so my gyn prescribed a compounded progesterone taken orally.

The way I understand it the pill still makes a pass through my liver, so how much is really absorbed? Is it better to take it in a sublinqual form such as trouche? Thank you.

Comments for Bio-identical Hormone Therapy

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Feb 14, 2011
Bio-identical Hormone Therapy
by: Wray

Hi Marsha I would have to know how much progesterone you are using, and if it contains oestrogen too. You mention hormone therapy, so I'm guessing it does. If it's the normal 20-40mg/day progesterone, it doesn't surprise me that your result was low. This amount doesn't raise levels to that of the luteal phase, see here. And if it contains oestrogen too, this opposes progesterone, so reducing the level. Oral progesterone is the least effective Delivery system. About 80% is destroyed by the gut and liver. The trouche is not much better either, as it has to be kept in the mouth for several minutes, plus it's also swallowed. More info on the link above. The best systems are injections, by all accounts painful, suppositories and creams. I recommend 100-200mg/day progesterone, are you using this amount? We run Saliva Tests regularly and from these have ascertained the ratio of progesterone to oestrogen should be 600:1 and over to feel well. Please check your ratio from your results, as it's this which is critical, not so much the quantity present. I'm not sure what age you are, so please see these two pages we have on Peri-menopause and Menopause. If you are using a combo cream, and should consider using only progesterone and a high amount, please see our page on Oestrogen Dominance too. Take care Wray


Jan 30, 2013
TBI and Hormone imbalance
by: Anonymous

I was doing desearch for my hormone imbalance that became extreme after a vehicle accident. I was looking for a physcian in Naples where I live. I wish I had this information after the accident. I believe I suffered a mild stroke durring the night. I lost function ofy mouth, tongue, and thought processes for about three days. My neurologist did not seem concerned so I did not think I should be either until you belped connect the dots. Thank you. My five children were also in the vehicle at the tkme too. I see some signs in them that I do not like so now I need to find a doctor that understands TBI in pediatrics. I would like to talk to you privately if thatbis possible.

Feb 01, 2013
TBI and Hormone imbalance
by: Wray

Hi there I'm so pleased the info on the site helped you. Donald Stein has been working on progesterone and Traumatic Brain Injury for close to 40 years. The results of a major study on TBI patients came out at the end of 2009, it was very successful. Other countries are now doing studies. When it will be used in general practice heaven only knows. There's no question about it's safety, even on babies, see a page I did on this here. Very high levels were used, with no signs of toxicity, only good came of them. The stroke or coma you were in doesn't surprise me after the accident, what does is your doctors views. I suppose they hadn't heard of progesterone and TBI. Further research came out of Emory University when they found a low level of vitamin D reduced the benefits of progesterone, see here, here and here. Please would you and your children have a vitamin D test done. I know you live in a sunny climate, but studies are finding this makes no difference to our levels, see here. Most of us spend 90% of our time indoors now, or we cover up with clothes or sunscreens when outside. We have two further pages which might interest you, How to use progesterone cream and Menstruation. Continued below

Feb 01, 2013
TBI and Hormone imbalance
by: Wray

Hi there The Stress of the accident would cause everything to crash, hormones, neurotransmitters, blood glucose, vitamin D, the B vitamins, amino acids and more. So I'm not surprised you now have a hormone imbalance. You probably still have Inflammation too, so large amounts of anti-oxidants, particularly the anti-inflammatory amino acids, should be taken to reverse the oxidative stress. I generally advise 100-200mg/day progesterone, but I feel nothing less than 400mg/day would help you. I'm not sure of the ages of your children, there is info about this on the how to use page I gave above. I know of no doctor experienced in TBI, progesterone and paediatrics, as you found yourself it's a wait and see attitude, if a severe coma drugs will be used. Over the course of 30 years, 50 have been tried, none successful. Progesterone and vitamin D will not be considered. There's a wonderful story on the TBI page, in which a mother applied our cream to her son in a coma. Proving that progesterone in cream form is as good as the IV transfusions normally given. We do know it's absorbed well, as a naturopath runs Saliva Tests for us periodically. If you wish to contact me, please do so via this form here. Take care Wray

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