Adrenals/anxiety

by anonomous
(canada)

Wray,

I have tried progesterone in the passed but increased my pcos symptoms (hair growth ect) I was using 200-400 so it makes so sense to me. I got off the cream the hair growth has reduced but am no experiencing sever anxiety, which I believe my cortisol has spiked trying to make up from the dose I had before. my question is if I start the progesterone again will it work because the progesterone receptors are being occupied and blocked by the higih affects of cortisol. Should I take it in combination with melatonin, or cortisol blocking agents? And if its my adrenals that are causig the problem, should dhea be taken with progesterone? and at what dose? do high/low cortisol play a factor?

Thank you

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Aug 22, 2013
Adrenals/anxiety
by: Wray

Hi there You were using a good amount, but how long did you use it for? The increase in your symptoms are explained on our page about Oestrogen Dominance. Briefly, progesterone stimulates oestrogen, it takes time or large amounts of progesterone to overcome this. We do have a page on PCOS you could look through. It's caused by oxidative stress, and high doses of antioxidants are needed to reverse it. Progesterone alone won't be enough, although it is needed too because levels are usually low due to anovulation. Stopping the cream has allowed your oestrogen to spike, hence the Anxiety. It's an excitatory, inflammatory hormone. Oestrogen stimulates glutamate, our most excitatory neurotransmitter, see here. It destroys beta-endorphin neurons in the brain, these produce endorphins which promote a feeling of well being and relaxation. And it increases free radicals, see here. Whereas progesterone protects against glutamate toxicity, it also increases BDNF (brain-derived neuroptrophic factor) in itself protective, see here and here. If glutamate is too high, it allows calcium, an excitatory mineral, to enter the cells. Progesterone also protects against calcium induced excitotoxicity, see here. If you think your cortisol is to high, then zinc reduces it, see here and here. Progesterone also increases zinc levels, whereas oestrogen reduces them as it increases copper. Copper is an antagonist to zinc. Melatonin can help if you're having sleep issues. Continued below

Aug 22, 2013
Adrenals/anxiety part 2
by: Wray

Hi there I would avoid the DHEA, see here, here, here and here. We do have a page you could look through on How to use progesterone cream. Take care Wray

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