Adenomyosis

by AG
(TX)

I am 43 years old, and have recently been diagnosed with Adenomyosis (my uterus is enlarged by 2 and 1/2 the normal size), as well as a thickening of the lining of the uterus (18mm). My Dr says is could just be peri-menopausal, but recommends removal of it. I've found on the internet that it could be due to pregnancies, birthing, c-section, miscarriage (I've had all). I also found info that it could be due to high levels of estrogen. On my own, I have cut out a large percentage of estrogen in my diet, and products. I have also been using Progestelle for about 3 weeks.

My question is, do you think that by doing this, my uterus will return to normal? My concern about removing it is, if it is enlarged because of excessive estrogen and I don't change my intake of it, then the excessive estrogen won't have the uterus to go to, and could create fibroids or worse. Is this correct?

Comments for Adenomyosis

Click here to add your own comments

Sep 05, 2009
Adenomyosis
by: Anonymous

Thick endometrial lining will cause excessive menstrual bleeding a few years before you enter menapause. This is the body's way of getting rid of excessive buildup. Some doctors perform curettage to scrape some of that excessive buildup and/or prescribe progestorone.

In my 40s, I was always being told by my gynecologists that the size of my uterus is large and has a thick lining. My periods were very heavy during my premenapousal years. I entered menopause at age 50. Good news is that, after menopause, our estrogen levels go down naturally, so you will not have to deal with the consequences of high estrogen levels after menopause.

Sep 09, 2009
Adenomyosis
by: Wray

Hi AG. Endometrial tissue is highly sensitive to both oestrogen and progesterone. Unfortunately oestrogen is an excitatory hormone, stimulating cells to grow, whereas progesterone is calming and prevents their growth. I don't know your other symptoms, but miscarriages are often caused by a lack of progesterone. So it seems to me you are short of progesterone, but you would need a high dose of about 200mg/day to see any effect, possibly more. Anything less won't help.

If you can use a high dose of progesterone each day, I believe the uterus will shrink, not down to it's size prior to the start of the adenomyosis, but certainly enough to prevent it's removal. You are in the beginning stages of peri-menopause, when the ratio of oestrogen to progesterone gets out of kilter. This is due to the anovulatory cycles which begin round about age 35. If you do have a hysterectomy fibroids can't form, as they are benign tumours found only in or on the uterus. It is essential as you say to reduce the excess oestrogen you have, cutting it out in your diet is good, although it's generally only found in livestock that have been given oestrogen for fattening, it's not found in plants.

Skin care is something else to watch for, as many products contain oestrogenic compounds. The safest way to reduce it, and the most beneficial too, is by using progesterone. You might care to read this web page. Please also read this one too, as oestrogen dominance often occurs and can be very disconcerting. Take care.

Nov 15, 2010
Andomyosis
by: kelly

Age 35, was on depo for three years. Got off depo-shot was taking 250mg every three months or 2 and a half months. Started to notice pain went to the doc and got diagnosed with andomyosis. I hate the side effects of the shot. I was going nuts all over my body. I am going to try the Balance creme bio-identical natural progesterone from the vitamin shot it says its a 2oz jar with a total of 1020 mg. How much should I take to reduce this uncomfortable feeling in my uterus cause I don't want to go back on the depo shot. Other alternative of course is the hysterectomy, not sure about that yet? Please how many tsp should I try? How many times a day? I am allergic to NSAIDS so can't go that route either. Started decadron 1/2 pill every three days. I do good on dexamethazone. I hope it will help as well.

Nov 15, 2010
adenomysis
by: kelly

Additional comment - I am on the nuva ring.

Nov 18, 2010
Andomyosis
by: Wray

Hi Kelly I recommend 100-200mg/day, although I feel you could do with the high amount initially. If you follow my suggestion you'll need to use between 6-12ml/day or 1 1/4 tsp to 2 1/2 tsp. For more info please see the page on How to use progesterone cream. The progesterone will have an uphill battle against the progestin and oestrogen you are getting from the Nuvaring. You might even have to use more than the suggested amount above. Adenomyosis is similar to Endometriosis, you might like to read our page on this. Both are inflammatory conditions. And please see our page on Contraceptives. Take care Wray

Jun 28, 2012
Adenomyosis at 25 years old
by: Michelle

I was diagnosed with Adenomyosis at 25 yrs - that was almost 9 yrs ago. Since then my uterus has increased to 16 weeks gestation. I tried Provera but that made me bleed for 8 months and I was hospitalised, the mirena coil was ejected from my body at every period (due to the large clots). All other drugs they tried failed to work and they do not want to do surgery because I want children. I started to do my own research since doctors have said there is nothing they can do until after I have children. I have researched Adenomyosis and started taking Myomin. There are two ways to block the action of estrogen. One is by attaching to its receptors (selective estrogen receptor modulation). This stops the signalling that triggers cell division in target tissues. Another method is aromatase inhibition, which reduces estrogen production by blocking its conversion from androstenedione and testosterone - myomin does both. I started taking it a week ago and my period is due, however I think its too early to see any benefits this time around. I have also read about progesterone cream but am a bit reluctant to take it because it tends to work initially then stops. Progresterone is highly fat soluble and once applied to your skin will store itself in your fat tissue. I have read that women have to come off it for up to 2 years for it to start working again. I may be entering the perimenopausal phase because I started my period at 10 yrs old and doctors have confirmed that my egg store is low. I am still hoping to conceive. My journey has been a difficult – I have yet to meet someone that was diagnosed with Adenomyosis at such a young age. I have been told it is rare but does happen. Good luck with your journey

Jun 29, 2012
Adenomyosis at 25 years old
by: Wray

Hi Michelle Unfortunately the provera was merely giving you a progestin, and lowering your progesterone levels in the process. And the mirena was giving you another progestin called levonorgestrel. This has been shown to lower progesterone levels, plus impeding the blood flow in the uterine arteries, see here and here. Levonorgestrel is derived from testosterone, so has androgenic properties. This is the prescribing information here, and please see here too. You might like to read these comments here from women who've used the Mirena. I'm glad it was rejected. Very interesting info about Myomin, I'm all in favour of using herbs and other natural substances to heal. The aromatase drugs are to my mind one of the worst, and come with many adverse side effects. Progesterone lowers oestrogen levels and also has aromatase inhibiting properties, see here, here, here, here, here, here and here. Although the site did have one thing wrong, or certainly didn't make it clear which sex they were referring to…'Abdominal obesity is associated with decreased testosterone levels (or hypogonadism) and increased estradiol levels.' The reverse in fact, testosterone increases visceral fat, see here and here. Oestrogen increases subcutaneous fat. Continued below.

Jun 29, 2012
Adenomyosis at 25 years old Part 2
by: Wray

Hi Michelle Progesterone doesn't stop working, or store in fat cells etc, there's info about this on our Progesterone Misconceptions page. I've been using it for 15 years now and it still works! Dr Dalton used it for over 50 years for her patients, and in none of her papers or books does she mention it stops working. What she does emphasise is that if enough is not used, it won't work. There's more info on this page here. If you want to know when you will enter menopause please ask your mother when she went into it. This gives a rough indication when daughters will. Peri-menopause begins 5 to 10 years before. The age of menarche doesn't always have a bearing on the age of menopause. We do have more info on our Menstruation page. And if you are wanting to fall pregnant, please have a look at our Pregnancy page. Please have a vitamin D test done. It's a potent antioxidant and anti-inflammatory and is invariably low in any inflammatory condition. I don't have any papers on adenomyosis, but please see these on fibroids, another inflammatory uterine condition, see here, here, here, here and here. And this paper here on oxidative stress, which is behind all inflammatory problems. For more info on How to use progesterone cream please look through this page. Take care Wray

Jul 31, 2012
Adenomyosis at 25 years old - response to Wray
by: Michelle

Yes – I know all about what progestin’s do to your body! I have read all about it and reel when I think about it. I am not obese – I exercise regularly, it is only my uterus which is enlarged and bulky. Unfortunately my mother was diagnosed with endometrial cancer at 36 years (I am 34 yrs old) so I have no idea when I will enter menopause and cannot gage it using my grandmother because she lived a healthy life in the country side – not interacting with any xenoestrogen and eating only organic fruit, veg and meat. In fact my grandmother had 1 of 5 children at 45 yrs old. I also had endometriosis, however this was successfully removed 5 years ago and my fibroids are very small. My main concern is the Adenomyosis and the damage estrogen dominance is causing to my fertility – I have a blocked fallopian tube. The Adenomyosis causes me to have very heavy flooding, I have been anemic for 10 years (my period last for 10 days) and have high erythrocyte sedimentation rate (ESR) due to the chronic inflammation my body endures every month. Ideally I am looking for a sympathetic holistic doctor who can perform hormone tests (e.g. estrogen and progesterone), other than vitamin D is there any other hormones you suggest I test? I went to my GP asking for the progesterone cream – but she said she couldn’t prescribe it to me. I’m a little worried about ordering online, I want to be able to trust what I am using. Through my research as well as taking myomin, I am also taking Magnesium, Vitamin B complex and fish oil. I really want to save my fertility and sanity (it is no fun passing clots that are a 5-10cm in diameter!)Any advice you can give on the type of hormone test to take and a holistic doctor in London would be appreciated.

Aug 01, 2012
Adenomyosis at 25 years old - response to Wray
by: Wray

Hi Michelle It's interesting you also had Endometriosis, another inflammatory uterine condition. It's caused by oxidative stress, as undoubtedly adenomyosis is too. Very large amounts of antioxidants are needed to reverse it. I also advise using about 500mg/day progesterone for endo, particularly if there's pain. But I see from your comment here that you have very heavy bleeding. At least 400mg/day progesterone is needed to stop this, if not more. Plus 2000-3000mg/day NAC (N-acetyl cysteine), this inhibits the MMPs which cause bleeding, see our Menstruation page for more info. NAC is also essential for endo or any condition caused by oxidative stress, see here. You might like to read this page here for encouragement. I don't know of any doctor in London, but you could contact Julienne via her website here. She's a registered EFT practitioner, who also knows a great deal about progesterone and vitamin D. All our Saliva Tests are carried out by Genova Diagnostics in Surrey, please contact them for help on this. I would always recommend having testosterone checked too. I see I forgot to give you info on vitamin D testing etc. Please see the Vitamin D Council, GrassrootsHealth and Birmingham Hospital websites. Blood levels should be 175-250nmol/L and not the 50nmol/L most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. Birmingham Hospital send out test kits for £25, the results come back about a week later. Continued below.

Click here to add your own comments

Join in and write your own page! It's easy to do. How? Simply click here to return to Progesterone faq.



Search over 5,700 pages on this site...

Do you have a progesterone deficiency?

This free questionnaire will tell you in 10 minutes

Just enter your email address and click the button...

Why do I ask for your email address? Simply so I can stay in touch. Your details will not be revealed to anyone


Do you have a question or concern?

See what's being discussed, ask for help, give your thoughts or experiences, or just browse...

See the FAQ pages...


Natural Progesterone Cream

Discover the facts...


Health care practitioners and therapists

Here's an
Associate Program
that may be a good fit for your practice


Your language

Translate this website into your language


Is this the future of medicine?

Watch this important video