12 weeks preg after 3 miscarriages

by CC
(Farmington, NM)

I am 32 and have a healthy 7 year old son and then I had 3 miscarriages. (2 at 10 weeks one at 14 weeks).

After the first two my doctor suspected a progesterone deficiencey. So with the next pregnancy, he started me on progesterone supplements. He kept me on them until I was almost 14 weeks. As soon as he took me off the supplements I miscarried. (a miscarriage at 14 weeks really sucks btw).

This time I am 12 weeks and he started me on progesterone supplements (oral) again as soon as I found out that I was pregnant at 7 weeks. (I have PCOS and my cycles are around 60 days in length, but I still ovulate around the normal time). He has been testing my progesterone levels twice a week (blood test) and says he will keep me on the supplements until my levels say its time to get off or around 16 weeks????

He does not want me to continue on progesterone for the entire pregnancy because he says it can cause problems with the baby's genitals. But I'm sure you can understand my apprehension of discontinuing the supplements.

Comments for 12 weeks preg after 3 miscarriages

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Sep 19, 2011
12 weeks preg after 3 miscarriages
by: Wray

Hi CC It's wonderful you had a child with a cycle length so long, plus battling with PCOS. I've not come across that before. Progesterone should never be stopped cold turkey, it will in all likelihood cause a miscarriage. In fact that is one of the prime reasons for miscarriages, often stress being behind it, as stress drops progesterone levels sharply. It shows how little your doctor knows about progesterone, we make over 400ng/ml per day in the third trimester of pregnancy, see the Medline website. If it did cause a problem with the baby's genitals, heaven help us all! Normally suppositories, intra-vaginal gels, or injections are given for recurrent miscarriages, or in IVF treatments. The amounts given are between 200 to 600mg/day, see here. But not in oral form, as most gets destroyed in the gut and liver, see our page on Delivery systems, and this paper here. As the paper says the transvaginal route of delivery avoids the metabolic inactivation of progesterone during its first liver pass. Transdermal delivery does the same. You don't mention how much progesterone you were taking, but was it in the region of 300mg/day? And is it progesterone, or a progestin? Please find this out, as progestins do cause foetal abnormalities. Were your estradiol, progesterone, testosterone and free testosterone levels checked while pregnant, as a low progesterone and high free testosterone are diagnostic features of miscarriages, see here. Saliva Tests are a better indication of hormone levels, we've found the ratio of progesterone to oestradiol should be 600:1 and over. I would strongly suggest you change to a delivery system which is effective, and to use sufficient. I have helped numerous women who've had recurrent miscarriages with a progesterone cream, they are well absorbed too. If you opt for a cream, I would advise using some in your vagina too, the progesterone travels rapidly to the uterus where it's needed. I've run out of space so will start a new comment below. Take care Wray

Sep 19, 2011
12 weeks preg after 3 miscarriages
by: W

Hi CC We do have a page on Pregnancy which explains how to use progesterone before and after conception. Please do not stop the progesterone cold turkey, it must be tapered off slowly, very slowly, and it can be used for the entire pregnancy. Vitamin D is not only vital for PCOS, for ovulation, conception and a successful pregnancy, but vital too for the foetus, see here, here, here, here and here. These are excellent videos to watch too, see here and here. Please consider taking some, the minimum should be 5000iu's per day. For more info see the Vitamin D Council, GrassrootsHealth and Birmingham Hospital websites. These are excellent videos to watch too, see here and here. You might consider taking taurine, this amino acid is also vital for the developing foetus, see here, here and here. Take care Wray

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